Charlotte Morningstar, more commonly known as Charlie, is the Hellborn princess of Hell, the founder of the Happy Hotel, and The daughter of Lucifer Morningstar and the estranged queen of Hell, Lilith.

Anthony, more commonly known as Angel Dust, is an A famous porn star and the first sinner the hotel is attempting to redeem, but his selfish actions of using the hotel as a rent-free living space threaten to jeopardize Charlie Morningstar's dream.

Alastor, also known as The Radio Demon, is a sinner demon and one of the many powerful Overlords of Hell, he is also the wickedly charismatic demon who has offered to assist Charlie Morningstar in her endeavors, albeit, for his own amusement.

Vaggie is an angel and former Exorcist. She is the deuteragonist of Hazbin Hotel and serves as the manager of the Hazbin Hotel.

Husk is a sinner demon, a grumpy gambler and magician who is also a former Overlord of Hell who lost his soul to Alastor in a gamble, he and Niffty have been summoned by him to help work at the Hazbin Hotel, with Husk being its front desk clerk and bartender.